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KMID : 1161520130170060397
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Animal Cells and Systems
2013 Volume.17 No. 6 p.397 ~ p.405
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Adrenal peripheral clock disruption leads to altered circadian behavioral responses to voluntary exercise in middle-aged female mice
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Kim Tae-Soo
Han Dong-Hee
Lee Yeon-Ju
Son Gi-Hoon
Kim Kyung-Jin
Kim Chang-Ju
Cho Se-Hyung
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Abstract
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We recently established an adrenal clock-disrupted transgenic mouse line (BMAS) that exhibits a dampened rhythm of corticosterone secretion and reduced amplitude of day/night activity. Here, we observe that voluntary wheel running increases the robustness and amplitude of both body temperature and home cage activity (HCA) rhythms in wild-type, but not in BMAS mice, but without affecting estrous cycle. Surprisingly, wheel running alters the HCA waveform of BMAS females in a way that preferentially increases the late nighttime (ZT21?ZT24) HCA. These results indicate that adrenal clock disruption causes the animals to respond differently to the voluntary exercise cue in middle-aged female mice.
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KEYWORD
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adrenal clock, exercise, biological rhythm, body temperature, home cage activity, middle-aged female mouse
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